Curt D Sigmund Selected Research

Pre-Eclampsia (Preeclampsia)

12/2023	Mitochondrial-targeted antioxidant attenuates preeclampsia-like phenotypes induced by syncytiotrophoblast-specific Gαq signaling.
1/2021	Team Science: American Heart Association's Hypertension Strategically Focused Research Network Experience.
1/2020	Reduced mRNA Expression of RGS2 (Regulator of G Protein Signaling-2) in the Placenta Is Associated With Human Preeclampsia and Sufficient to Cause Features of the Disorder in Mice.
10/2018	Arginine vasopressin infusion is sufficient to model clinical features of preeclampsia in mice.
1/2018	Elevated vasopressin in pregnant mice induces T-helper subset alterations consistent with human preeclampsia.
11/2015	Vasopressin: the missing link for preeclampsia?
1/2015	Pregnant mice lacking indoleamine 2,3-dioxygenase exhibit preeclampsia phenotypes.
3/2007	The -20 and -217 promoter variants dominate differential angiotensinogen haplotype regulation in angiotensinogen-expressing cells.

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Curt D Sigmund Research Topics

Disease

66	Hypertension (High Blood Pressure) 12/2023 - 01/2002
8	Obesity 12/2023 - 06/2004
8	Pre-Eclampsia (Preeclampsia) 12/2023 - 03/2007
7	Atherosclerosis 07/2023 - 05/2004
5	Weight Gain 01/2022 - 03/2011
5	Polydipsia 01/2021 - 03/2011
5	Inflammation (Inflammations) 01/2016 - 05/2004
4	AIDS-Related Complex (ARC) 12/2023 - 04/2011
3	Cardiovascular Diseases (Cardiovascular Disease) 07/2023 - 01/2005
3	Heart Failure 07/2023 - 05/2004
3	Essential Hypertension 01/2022 - 03/2007
3	Dehydration (Water Stress) 01/2018 - 02/2015
3	Insulin Resistance 11/2017 - 03/2010
3	Body Weight (Weight, Body) 01/2016 - 03/2009
2	Proteinuria 12/2023 - 02/2006
2	Heart Diseases (Heart Disease) 01/2021 - 01/2020
2	Neoplasms (Cancer) 11/2019 - 05/2004
2	Vascular Diseases (Vascular Disease) 01/2018 - 01/2017
2	Vascular Remodeling 12/2016 - 01/2016
2	Pathologic Constriction (Stenosis) 03/2016 - 03/2013
2	Fibrosis (Cirrhosis) 01/2016 - 03/2010
2	Polyuria 03/2013 - 03/2011
2	Hypertrophy 04/2008 - 03/2008
2	Ganglion Cysts (Ganglion) 09/2002 - 01/2002
1	Hypernatremia 11/2022
1	Acidosis 01/2022
1	Albuminuria 01/2021
1	Stroke (Strokes) 01/2021
1	Diabetes Mellitus 11/2018
1	Cardiovascular Abnormalities 11/2018

Drug/Important Bio-Agent (IBA)

25	SaltsIBA 01/2023 - 09/2002
19	Angiotensin IIIBA 07/2023 - 02/2002
18	ReninIBA 01/2023 - 01/2002
15	Peroxisome Proliferator-Activated Receptors (PPAR)IBA 01/2021 - 03/2010
14	AngiotensinogenIBA 12/2017 - 02/2002
11	Desoxycorticosterone Acetate (DOCA)FDA Link 01/2023 - 03/2011
11	Desoxycorticosterone (Deoxycorticosterone)IBA 01/2023 - 03/2013
10	Acetates (Acetic Acid Esters)FDA Link 01/2023 - 03/2013
7	Vasopressins (Vasopressin)IBA 01/2022 - 01/2002
6	Peptides (Polypeptides)IBA 12/2023 - 05/2004
6	Proteins (Proteins, Gene)FDA Link 01/2022 - 02/2005
6	AngiotensinsIBA 01/2021 - 02/2002
6	LeptinIBA 01/2021 - 03/2009
6	PPAR gammaIBA 03/2010 - 06/2004
5	Superoxides (Superoxide)IBA 12/2023 - 10/2002
5	Type 1 Angiotensin ReceptorIBA 07/2023 - 02/2015
5	SodiumIBA 11/2022 - 03/2011
4	Messenger RNA (mRNA)IBA 12/2023 - 02/2005
4	Nitric Oxide (Nitrogen Monoxide)FDA Link 01/2022 - 10/2002
4	Arginine Vasopressin (Argipressin)IBA 10/2018 - 09/2002
3	Hormones (Hormone)IBA 12/2023 - 11/2015
3	ArrestinIBA 07/2023 - 01/2021
3	RNA (Ribonucleic Acid)IBA 01/2023 - 03/2016
3	Losartan (Cozaar)FDA LinkGeneric 01/2021 - 09/2002
3	Cullin Proteins (Cullins)IBA 10/2018 - 07/2015
3	CytokinesIBA 01/2018 - 05/2004
3	Glucose (Dextrose)FDA LinkGeneric 11/2017 - 03/2010
3	Calcium-Calmodulin-Dependent Protein Kinase Type 2IBA 12/2016 - 11/2011
3	ThiazolidinedionesIBA 12/2015 - 01/2005
3	NADPH Oxidases (NAD(P)H oxidase)IBA 03/2015 - 06/2008
3	LigandsIBA 05/2013 - 01/2005
3	NG-Nitroarginine Methyl Ester (L-NAME)IBA 06/2008 - 06/2005
2	Protein Isoforms (Isoforms)IBA 12/2023 - 12/2016
2	Reactive Oxygen Species (Oxygen Radicals)IBA 12/2023 - 01/2006
2	GTP-Binding Proteins (G-Protein)IBA 01/2023 - 01/2020
2	Vasopressin Receptors (Arginine Vasopressin Receptor)IBA 01/2022 - 09/2002
2	Phosphotransferases (Kinase)IBA 10/2018 - 06/2015
2	Ligases (Synthetase)IBA 12/2017 - 08/2008
2	UbiquitinIBA 12/2017 - 08/2008
2	Insulin (Novolin)FDA Link 11/2016 - 05/2013
2	ApolipoproteinsIBA 01/2016 - 05/2013
2	Pioglitazone (Actos)FDA Link 07/2015 - 03/2013
2	EnzymesIBA 01/2015 - 11/2011
2	Cytoplasmic and Nuclear Receptors (Nuclear Receptors)IBA 05/2013 - 10/2012
2	Cre recombinaseIBA 04/2011 - 02/2002
1	mitoquinoneIBA 12/2023
1	AntioxidantsIBA 12/2023
1	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 07/2023
1	ArrestinsIBA 07/2023
1	salicylhydroxamic acid (SHAM)IBA 01/2023
1	Prorenin ReceptorIBA 01/2023
1	2-(4-toluidino)-6-naphthalenesulfonic acid (TNS)IBA 01/2023
1	Serotonin (5 Hydroxytryptamine)IBA 01/2022
1	Aquaporin 2IBA 01/2022
1	ElectrolytesIBA 01/2022
1	Biomarkers (Surrogate Marker)IBA 01/2021
1	Sar-Arg-Val-Tyr-Ile-His-Pro-Ala-OHIBA 01/2021
1	MelanocortinsIBA 01/2021
1	Mutant Proteins (Protein, Mutant)IBA 01/2020
1	Histone Deacetylases (Histone Deacetylase)IBA 01/2020
1	Endothelins (Endothelin)IBA 01/2020
1	Cyclin EIBA 11/2019
1	CyclinsIBA 11/2019
1	Vasodilator Agents (Vasodilators)IBA 01/2019
1	Type 5 Cyclic Nucleotide PhosphodiesterasesIBA 01/2019
1	Prostaglandins FIBA 10/2018
1	Tyrosine (L-Tyrosine)FDA Link 10/2018

Therapy/Procedure

5	Therapeutics 03/2020 - 01/2007
2	Intravenous Injections 09/2002 - 01/2002
1	Sodium-Restricted Diet (Diet, Sodium Restricted) 11/2018